A case of uncommon cause of hypercholesterolemia

Sempastian Filippas-Ntekouan, Maria Kosmidou, Constantinos Tellis, Alexandros D Tselepis, Haralampos Milionis

Abstract


Cholestasis is a rare cause of secondary hypercholesterolemia which may be attributed to increased production of an abnormal lipoprotein (apo), known as Lp-X. We present the case of a patient admitted due to cholestatic jaundice and pruritus and showed excess hypercholesterolemia due to increased production of Lp-X. The patient was diagnosed with an adenocarcinoma of the pancreas. Surgical restoration of the bile flow resulted in normalization of lipids.


Keywords


Secondary hypercholesterolemia; lipoprotein X; cholestasis; jaundice

Full Text:

PDF

References


Castro Cabezas, M., B. Burggraaf, and B. Klop, Dyslipidemias in clinical practice. Clin Chim Acta, 2018. 487: p. 117-125

Kopin, L. and C. Lowenstein, Dyslipidemia. Ann Intern Med, 2017. 167(11): p. Itc81-itc96

Heimerl, S., et al., Lipid profiling of lipoprotein X: Implications for dyslipidemia in cholestasis. Biochim Biophys Acta, 2016. 1861(8 Pt A): p. 681-7

Seidel, D., P. Alaupovic, and R.H. Furman, A lipoprotein characterizing obstructive jaundice. I. Method for quantitative separation and identification of lipoproteins in jaundiced subjects. J Clin Invest, 1969. 48(7): p. 1211-23

Seidel, D., et al., A lipoprotein characterizing obstructive jaundice. II. Isolation and partial characterization of the protein moieties of low density lipoproteins. J Clin Invest, 1970. 49(12): p. 2396-407

Hoefner, D.M., et al., Development of a rapid, quantitative method for LDL subfractionation with use of the Quantimetrix Lipoprint LDL System. Clin Chem, 2001. 47(2): p. 266-74

Fellin, R. and E. Manzato, Lipoprotein-X fifty years after its original discovery. Nutr Metab Cardiovasc Dis, 2019. 29(1): p. 4-8

Walli, A.K. and D. Seidel, Role of lipoprotein-X in the pathogenesis of cholestatic hypercholesterolemia. Uptake of lipoprotein-X and its effect on 3-hydroxy-3-methylglutaryl coenzyme A reductase and chylomicron remnant removal in human fibroblasts, lymphocytes, and in the rat. J Clin Invest, 1984. 74(3): p. 867-79

Ritland, S. and E. Gjone, Quantitative studies of lipoprotein-X in familial lecithin: cholesterol acyltransferase deficiency and during cholesterol esterification. Clin Chim Acta, 1975. 59(2): p. 109-19

Suzuki, L., et al., Lipoprotein-X in cholestatic patients causes xanthomas and promotes foam cell formation in human macrophages. J Clin Lipidol, 2017. 11(1): p. 110-118




DOI: http://dx.doi.org/10.23803/hja.v9i4.198

DOI (PDF): http://dx.doi.org/10.23803/hja.v9i4.198.g167

Refbacks

  • There are currently no refbacks.